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Nimodipine, sold under the brand name Nimotop among others, is a calcium channel blocker originally developed for the treatment of high blood pressure. It is not frequently used for this indication, but has shown good results in preventing a major complication of subarachnoid hemorrhage (a form of cerebral hemorrhage) termed vasospasm; this is now the main use of nimodipine.
It was patented in 1971 and approved for medical use in the US in 1988. It was approved for medical u…



Nov 07, 2017 · Nimodipine is a yellow crystalline substance, practically insoluble in water. Nimodipine capsules are formulated as soft gelatin capsules for oral administration. Each liquid filled capsule contains 30 mg of Nimodipine in a vehicle of glycerin, peppermint oil and polyethylene glycol.

Find patient medical information for Nimodipine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

Mar 15, 2019 · Nimodipine is a calcium channel blocker that is used to prevent brain damage caused by reduced blood flow to the brain resulting from aneurysm (a dilated or ruptured blood vessel in the brain).

Accidental injection of nimodipine can cause serious (rarely fatal) side effects (such as low blood pressure, slow heartbeat). Consult your doctor or pharmacist for details. USES: Nimodipine is used to decrease problems due to a certain type of bleeding in the brain (subarachnoid hemorrhage-SAH).Nimodipine is called a calcium channel blocker ...

Medscape - Indication-specific dosing for Nymalize (nimodipine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.

Sep 09, 2008 · Nimodipine is a yellow crystalline substance, practically insoluble in water. NIMOTOP® (nimodipine) capsules are formulated as soft gelatin capsules for oral administration. Each liquid filled capsule contains 30 mg of nimodipine in a vehicle of glycerin, peppermint oil, purified water and polyethylene glycol 400.

Nimodipine enhances the survival of dopaminergic substantia nigra neurons. Nimodipine is a potent L-type Ca 2+ channel antagonist. Features and Benefits This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC ® 1280), a biologically annotated collection of high-quality, ready-to-screen compounds.

Jun 15, 2017 · Nimodipine and some anaesthetics can interact, meaning that unwanted effects are more likely. Can nimodipine cause problems? Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with nimodipine.

Nimodipine is a dihydropyridine calcium channel blocker derivative, which is used in the treatment of cerebrovascular disorders. Nimodipine is rapidly absorbed from the gastrointestinal tract following oral administration, but undergoes extensive first-pass metabolism in the liver.

Nimodipine is a CYP3A4 substrate and apalutamide is a strong CYP3A4 inducer. Nimodipine plasma concentration and efficacy may be significantly reduced when concomitantly administered with strong CYP3A4 inducers. Apomorphine: (Moderate) Use of calcium-channel blockers and apomorphine together can increase the hypotensive effects of apomorphine ...

Search results for nimodipine at Sigma-Aldrich. Compare Products: Select up to 4 products. *Please select more than one item to compare

NIMODIPINE is a calcium-channel blocker. This medicine is used to treat subarachnoid hemorrhage.This is a condition in which there is bleeding into the space around the brain that causes severe headaches and stiff neck. The lowest GoodRx price for the most common version of generic Nimodipine is around $108.43, 87% off the average retail price of $870.80.

Nimodipine is a second generation calcium channel blocker used in the treatment of cerebral vasospasm after subarachnoid hemorrhage. Nimodipine is not widely used and has not been implicated in causing clinically apparent acute liver injury.

Nimodipine is a calcium channel blocker. It relaxes the narrow blood vessels in the brain and makes the blood flow more easily. This prevents brain damage after bleeding around the brain.

Jan 01, 2017 · Nimodipine (By mouth) nye-MOE-di-peen. Helps reduce brain damage caused by bleeding in the brain from a burst blood vessel. This medicine is a calcium channel blocker (CCB). Drug classes. Cardiovascular Agent (About this - PubMed Health) Uses Uses of This Medicine

Jul 24, 2019 · Nimodipine is a calcium channel blocker that is used to prevent brain damage caused by reduced blood flow to the brain resulting from aneurysm (a dilated or ruptured blood vessel in the brain).. Nimodipine may also be used for purposes not listed in this medication guide.

blockers. Nimodipine is isopropyl 2 - methoxyethyl 1, 4 - dihydro - 2, 6 - dimethyl - 4 - (m-nitrophenyl) - 3, 5 - pyridinedicarboxylate It has a molecular weight of 418.5 and a molecular formula of C21H26N2O7. The structural formula is: Nimodipine is a yellow crystalline substance, practically insoluble in water.

Dec 14, 2018 · Nimodipine is a yellow crystalline substance, practically insoluble in water. Nimodipine capsules are formulated as soft gelatin capsules for oral administration. Each liquid filled capsule contains 30 mg of nimodipine USP.

Grapefruit juice (in oral nimodipine administration) reduces effectiveness of nimodipine. • Phenytoin oral dose decreases nimodipine oral bioavailability by 7-fold. • Sodium valproate oral dose increases the bioavailability of oral nimodipine dose by 50%. Adverse Effects 1,2,3 • Hypotension, especially in patients with a history of ...



Nimodipine is a calcium channel blocker. Nimodipine relaxes (widens) blood vessels and improves blood flow. Nimodipine is used to prevent brain damage caused by reduced blood flow to the brain resulting from aneurysm (AN-yor-iz-m), a dilated or ruptured blood vessel in the brain. Nimodipine may also be used for purposes...

Sep 09, 2008 · Nimotop (nimodipine) Capsules are calcium channel blockers indicated for the improvement of neurological outcome by reducing the incidence and severity of ischemic deficits in patients with subarachnoid hemorrhage from ruptured intracranial berry aneurysms regardless of their post-ictus neurological condition (i.e., Hunt and Hess Grades I-V). Nimotop is available in generic form.

Administration of nimodipine also presents specific issues for patients who are critically ill. The nimodipine capsules available in the United States consist of a tough, flexible outer skin and a small amount of peppermint oil-based solution containing 30 mg of nimodipine.

Precautions. Drug information provided by: IBM Micromedex It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to …

Nimotop: Adalat CC, Adalat LA (UK), Adalat P.A., Adalat Retard (UK), Adalat XL, Adipine (UK), Afeditab CR, Angiopine (UK), Apo-Nifed, Calchan (UK), Cardilate MR (UK ...

Nimodipine is a dihydropyridine calcium-channel blocker. Indications and dose Prevention of ischaemic neurological defects following aneurysmal subarachnoid haemorrhage

Nimodipine is used to treat symptoms resulting from a ruptured blood vessel in the brain (subarachnoid hemorrhage). It works by increasing the blood flow to injured brain tissue. This medicine is available only with your doctor's prescription.

Participants first take escalating doses of nimodipine for a period of four weeks, then the maximum tolerated dose for another four weeks, and then undergo one week of tapering off. This open-label trial aims primarily to determine the maximum tolerated dose of nimodipine in this patient population as preparation for further efficacy trials.

Apr 17, 2019 · Nimodipine. calcium channel antagonist that has is known to have some selectivity for the cerebral circulation; used in cerebral aneurysm surgery to decrease perioperative vasospasm associated with blood in the cranium and also from perioperative handling/disruption of cerebral blood vessels during clipping (after a rupture of a berry aneurysm)

Mohammed A. Al-Omar, in Profiles of Drug Substances, Excipients and Related Methodology, 2005. Publisher Summary. Nimodipine is a dihydropyridine calcium channel blocker derivative, which is used in the treatment of cerebrovascular disorders. Nimodipine is rapidly absorbed from the gastrointestinal tract following oral administration, but undergoes extensive first-pass metabolism in the liver.

Jun 22, 2002 · I assume you're giving Nimodipine for cerebral vasospasm prevention, so, in that case, the way to give it is to squirt the contents of the capsule under the tongue for absorption through the buccal mucosa. NEVER, EVER crush an enteric coated tablet--it isn't designed for absorption at the same rate or in the same manner as a liquid.

Ohman J, Heiskanen O. Effect of nimodipine on the outcome of patients after aneurysmal subarachnoid hemorrhage and surgery. J Neurosurg 1988; 69:683. Harders A, Kakarieka A, Braakman R. Traumatic subarachnoid hemorrhage and its treatment with nimodipine.

Jan 14, 2020 · The manufacturers of nimodipine capsules and the Institute for Safe Medication Practices (ISMP) both recommend labeling the syringe containing nimodipine for administration with the phrase, "For Oral Use Only." Once the contents are given via a nasogastric tube, wash the tube with 30 mL of 0.9% normal saline.

Oct 21, 2019 · Nimodipine - Last updated on February 5, 2020 ©2020 Memorial Sloan Kettering Cancer Center. Educational Resources. Log in to print or send this list to your patient and save lists of resources you use frequently. Add resources to your list by clicking the checkbox next to the title.

Oral nimodipine is a proven and valuable treatment to prevent or limit the severity of cerebral vasospasm. Type of Measure: Process Improvement Noted As: Increase in the rate Numerator Statement: SAH patients for whom nimodipine treatment …

Nimodipine. One of the main complications of a subarachnoid haemorrhage is secondary cerebral ischaemia. This is where the supply of blood to the brain becomes dangerously reduced, disrupting the normal functions of the brain, causing brain damage. You'll usually be given a medication called nimodipine to reduce the chances of this happening.

⚠ WARNING: This product can expose you to chemicals including Nimodipine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov. Citations for Nimodipine.

Management of vasospasm was asked about in Question 10 from the first paper of 2007, and again in Question 5 from the first paper of 2013. Apart from discredited approaches like the "Triple H" therapy, there is little to talk about in terms of prevention apart from nimodipine. The aim of this chapter is to bring together the evidence for this therapy.

Comments on nimodipine. What made you want to look up nimodipine?Please tell us where you read or heard it (including the quote, if possible).

Oct 10, 2017 · Nimodipine is a dihydropyridine calcium channel blocker with particular cerebrovascular effect. Nimodipine increases cerebral perfusion, particularly in poorly perfused areas, by arterial dilatation, an effect which is proportionately greater in smaller than in larger vessels.

niMODipine is a topic covered in the Davis's Drug Guide.. To view the entire topic, please sign in or purchase a subscription.. Nursing Central is an award-winning, complete mobile solution for nurses and students. Look up information on diseases, tests, and procedures; then consult the database with 5,000+ drugs or refer to 65,000+ dictionary terms.

Nimodipine plasma concentration can also be increased in the presence of moderate and weak inhibitors of CYP3A4. If nimodipine is concomitantly administered with these drugs, blood pressure should be monitored, and a reduction of the nimodipine

Izquierdo (1990) Nimodipine and the recovery of memory. TiPS 11 309 PMID: 2203191. Kappelle et al (1994) Beneficial effect of the Ca 2+ antagonist, nimodipine, on existing diabetic neuropathy in the BB/Wor rat. Br.J.Pharmacol.

Nimodipine is usually started as soon as possible after the start of bleeding in the brain, usually within 4 days. Nimodipine is usually taken every 4 hours or as directed by your doctor. Take the tablet form of this medication by mouth with a full glass of water (8 ounces/240 milliliters) unless …

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